A molecular take on Aesop's The oak and the reeds.
biomechanical · Level V
Where this comes from
- Record sourced from PubMed, PMID 25768898.
- Also identified by DOI 10.1016/j.cell.2015.02.036.
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Abstract
Ngo et al. use single-molecule methods to show that DNA can be more readily displaced from one side of a nucleosome relative to the other side. This unexpected mechanical asymmetry may offer a path of least resistance, allowing RNA polymerases to traverse nucleosomes if they approach from the correct direction.
Medical subject headings
- DNA
- Nucleosomes