Transcription gets to the checkpoint.

Laver, John D; Lipshitz, Howard D · Cell · 2015

basic_science · Level V

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Abstract

The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition.

Medical subject headings