A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25771015.
- Also identified by DOI 10.1016/j.biomaterials.2015.02.013 and PMC identifier 4387846.
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Abstract
An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.
Medical subject headings
- Endosomes
- Molecular Probes
- Nanoparticles
- Nanotechnology