Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia -- The PUSH-PATH3 Study.
Level II
Where this comes from
- Record sourced from PubMed, PMID 25774058.
- Also identified by DOI 10.3899/jrheum.141037.
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Abstract
To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl). Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status. Prednisone can be used safely in symptomatic HF patients with hyperuricemia.
Medical subject headings
- Gout Suppressants
- Heart Failure
- Hyperuricemia
- Prednisone