PLEKHA5: A Key to Unlock the Blood-Brain Barrier?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25779946.
- Also identified by DOI 10.1158/1078-0432.CCR-14-2604.
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Abstract
Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.
Medical subject headings
- Brain Neoplasms
- Intracellular Signaling Peptides and Proteins
- Melanoma