Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25786110.
- Also identified by DOI 10.1371/journal.pone.0120807 and PMC identifier 4364741.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis. PTX3 bound acapsular meningococcus, Neisseria-derived outer membrane vesicles (OMV) and 3 selected meningococcal antigens (GNA0667, GNA1030 and GNA2091). PTX3-recognized microbial moieties are conserved structures which fulfil essential microbial functions. Ptx3-deficient mice had a lower antibody response in vaccination protocols with OMV and co-administration of PTX3 increased the antibody response, particularly in Ptx3-deficient mice. Administration of PTX3 reduced the bacterial load in infant rats challenged with Neisseria meningitidis. These results suggest that PTX3 recognizes a set of conserved structures from Neisseria meningitidis and acts as an amplifier/endogenous adjuvant of responses to this bacterium.
Medical subject headings
- Adjuvants, Immunologic
- Antibodies, Bacterial
- Antigens, Bacterial
- C-Reactive Protein
- Meningitis, Meningococcal
- Meningococcal Vaccines
- Neisseria meningitidis
- Serum Amyloid P-Component