Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25789928.
- Also identified by DOI 10.1371/journal.pone.0117519 and PMC identifier 4366204.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Circadian rhythms are certain periodic behaviours exhibited by living organism at different levels, including cellular and system-wide scales. Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding. These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock. These entities, along with abstracted feeding induced signals were modelled collectively in this study using Petri Nets. The properties of the model show that the circadian system itself is strongly robust, and is able to continually evolve. The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.
Medical subject headings
- Circadian Clocks
- Food
- Hepatocytes
- Models, Biological