Consequences of Disrupted Notch Signaling in Bladder Cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25791514.
- Also identified by DOI 10.1016/j.eururo.2015.02.034.
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Abstract
The Notch pathway, which controls stem cell maintenance and cell differentiation, is activated in certain cancers and therefore constitutes a therapeutic target. Especially in invasive urothelial carcinoma, the pathway is inactivated instead, and drugs inhibiting Notch signaling are likely contra-indicated.
Medical subject headings
- Receptors, Notch
- Tumor Suppressor Proteins
- Urinary Bladder Neoplasms