The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval.
rct · Level II
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- Record sourced from PubMed, PMID 25794112.
- Also identified by DOI 10.1213/ANE.0000000000000693.
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Abstract
Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early. During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system. Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL). Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.
Medical subject headings
- Ambulances
- Anesthesia, Closed-Circuit
- Asphyxia Neonatorum
- Emergency Medical Services
- Hypothermia, Induced
- Point-of-Care Systems
- Respiration, Artificial
- Ventilators, Mechanical
- Xenon