Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25800697.
- Also identified by DOI 10.1038/ncomms7570 and PMC identifier 4372816.
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Abstract
High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.
Medical subject headings
- Chalcogens
- Coloring Agents
- Gold
- Heterocyclic Compounds, 3-Ring
- Metal Nanoparticles
- Spectrum Analysis, Raman