Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25800862.
- Also identified by DOI 10.1002/adhm.201500053.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.
Medical subject headings
- Chondrogenesis
- Collagen
- Hyaluronic Acid
- SOX Transcription Factors
- Tissue Scaffolds
- Transforming Growth Factor beta3