The functions of atrial strands interdigitating with and penetrating into sinoatrial node: a theoretical study of the problem.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25803434.
- Also identified by DOI 10.1371/journal.pone.0118623 and PMC identifier 4372425.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The sinoatrial node (SAN)-atrium system is closely involved with the activity of heart beating. The impulse propagation and phase-locking behaviors of this system are of theoretical interest. Some experiments have revealed that atrial strands (ASs) interdigitate with and penetrate into the SAN, whereby the SAN-atrium system works as a complex network. In this study, the functions of ASs are numerically investigated using realistic cardiac models. The results indicate that the ASs penetrating into the central region of the SAN play a major role in propagating excitation into the atrium. This is because the threshold SAN-AS coupling for an AS to function as an alternative path for propagation is lower at the center than at the periphery. However, ASs penetrating into the peripheral region have a great effect in terms of enlarging the 1:1 entrainment range of the SAN because the automaticity of the SAN is evidently reduced by ASs. Moreover, an analytical formula for approximating the enlargement of the 1:1 range is derived.
Medical subject headings
- Atrial Function
- Heart Atria
- Models, Biological
- Sinoatrial Node