Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 25808990.
- Also identified by DOI 10.1038/ncomms7669.
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Abstract
Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 receptor D (IL-17RD) in negatively regulating Toll-like receptor (TLR)-induced responses. Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock. We demonstrate that the intracellular Sef/IL-17R (SEFIR) domain of IL-17RD targets TIR adaptor proteins to inhibit TLR downstream signalling thus revealing a paradigm involving cross-regulation of members of the IL-17R and TLR families.
Medical subject headings
- Gene Expression Regulation
- Immunity, Innate
- Interferon Regulatory Factors
- NF-kappa B
- Receptors, Interleukin
- Shock, Septic
- Toll-Like Receptors