Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25810312.
- Also identified by DOI 10.1126/scitranslmed.aaa6853 and PMC identifier 4425354.
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Abstract
Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.
Medical subject headings
- Hematopoietic Stem Cell Transplantation
- Immunotherapy
- Organ Transplantation