Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25811353.
- Also identified by DOI 10.1021/nl504610d and PMC identifier 4518714.
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Abstract
We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology.
Medical subject headings
- Epithelium
- Kidney Tubules, Proximal
- Nanocapsules
- Polyethylene Glycols
- Polyglactin 910