A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25816319.
- Also identified by DOI 10.1371/journal.pone.0117634 and PMC identifier 4376863.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
Medical subject headings
- Actin Cytoskeleton
- Models, Biological
- Muscle Contraction
- Muscle, Skeletal