Probing the interactions of intrinsically disordered proteins using nanoparticle tags.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25822629.
- Also identified by DOI 10.1021/acs.nanolett.5b00073.
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Abstract
The structural plasticity of intrinsically disordered proteins serves as a rich area for scientific inquiry. Such proteins lack a fix three-dimensional structure but can interact with multiple partners through numerous weak bonds. Nevertheless, this intrinsic plasticity possesses a challenging hurdle in their characterization. We underpin the intermolecular interactions between intrinsically disordered neurofilaments in various hydrated conditions, using grafted gold nanoparticle (NP) tags. Beyond its biological significance, this approach can be applied to modify the surface interaction of NPs for the creation of future tunable "smart" hybrid biomaterials.
Medical subject headings
- Intermediate Filaments
- Intrinsically Disordered Proteins
- Metal Nanoparticles