Robust enumeration of cell subsets from tissue expression profiles.
basic_science · Level V
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- Record sourced from PubMed, PMID 25822800.
- Also identified by DOI 10.1038/nmeth.3337 and PMC identifier 4739640.
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Abstract
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types. CIBERSORT should enable large-scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu/).
Medical subject headings
- Palatine Tonsil
- Tissue Culture Techniques
- Tissue Preservation
- Transcriptome