MCF-7 cells--changing the course of breast cancer research and care for 45 years.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25828948.
- Also identified by DOI 10.1093/jnci/djv073.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
It is 45 years since a pleural effusion from a patient with metastatic breast cancer led to the generation of the MCF-7 breast cancer cell line. MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes. But of the authors for the nearly 25000 scientific publications that used this cell line, how many know the unique story of its isolation and development? In this commentary we will review the past, present, and future of research using MCF-7 breast cancer cells.
Medical subject headings
- Adenocarcinoma
- Biomarkers, Tumor
- Breast Neoplasms
- MCF-7 Cells
- Molecular Targeted Therapy
- Pleural Effusion, Malignant
- Receptors, Estrogen