An unusual complex karyotype in myopericytoma.
case_report · Level V
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- Record sourced from PubMed, PMID 25829759.
- Also identified by DOI 10.1016/j.jor.2015.01.015 and PMC identifier 4353992.
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Abstract
Myopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells. We present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma. Some of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.