GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25831231.
- Also identified by DOI 10.1021/nn507382n.
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Abstract
GNeosomes, lysosomotropic lipid vesicles decorated with guanidinoneomycin, can encapsulate and facilitate the cellular internalization and lysosomal delivery of cargo ranging from small molecules to high molecular weight proteins, in a process that is exclusively dependent on cell surface glycosaminoglycans. Their cellular uptake mechanism and co-localization with lysosomes, as well as the delivery, release, and activity of internalized cargo, are quantified. GNeosomes are proposed as a universal platform for lysosomal delivery with potential as a basic research tool and a therapeutic vehicle.
Medical subject headings
- Aminoglycosides
- Drug Carriers
- Lysosomes
- Nanostructures