Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25832647.
- Also identified by DOI 10.1093/bib/bbv013 and PMC identifier 4652618.
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Abstract
Cancer results from dysregulation of multiple steps of gene expression programs. We review how transcriptome profiling has been widely explored for cancer classification and biomarker discovery but resulted in limited clinical impact. Therefore, we discuss alternative and complementary omics approaches.
Medical subject headings
- Evolution, Molecular
- Neoplasms
- Transcriptome