Dissecting risk haplotypes in sporadic Alzheimer's disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25842969.
- Also identified by DOI 10.1016/j.stem.2015.03.010.
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Abstract
Understanding how genetic risk variants contribute to complex diseases is crucial for predicting disease susceptibility and developing patient-tailored therapies. In this issue of Cell Stem Cell, Young et al. (2015) dissect the function of common non-coding risk haplotypes in the SORL1 locus in the pathogenesis of sporadic Alzheimer's disease using patient-derived induced pluripotent stem cells.
Medical subject headings
- Alzheimer Disease
- Induced Pluripotent Stem Cells
- LDL-Receptor Related Proteins
- Membrane Transport Proteins
- Neurons
- Serum Amyloid A Protein