An epigenomic road map for endoderm development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25842970.
- Also identified by DOI 10.1016/j.stem.2015.03.006.
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Abstract
While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives pancreas and liver.
Medical subject headings
- Embryonic Stem Cells
- Endoderm
- Enhancer Elements, Genetic
- Gastrula
- Pancreas