The lncRNA Pnky in the brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25842971.
- Also identified by DOI 10.1016/j.stem.2015.03.015.
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Abstract
Long noncoding RNAs (lncRNAs) influence diverse cellular processes and have been implicated in regulating stem cell properties. Now in Cell Stem Cell, Ramos et al. (2015) demonstrate that the neural-specific lncRNA Pnky regulates neuronal differentiation from neural stem cells and mediates RNA splicing through interactions with polypyrimidine tract-binding protein 1 (PTBP1).
Medical subject headings
- Brain
- Embryonic Stem Cells
- Heterogeneous-Nuclear Ribonucleoproteins
- Neural Stem Cells
- Neurons
- Polypyrimidine Tract-Binding Protein
- RNA, Long Noncoding