Close encounters of the lysosome-peroxisome kind.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25860602.
- Also identified by DOI 10.1016/j.cell.2015.03.046 and PMC identifier 4435959.
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Abstract
Lysosomes provide a major source for cellular cholesterol; however, most of this cholesterol is trafficked to the plasma membrane via unknown mechanisms. Chu et al. identify an unexpected role for peroxisomes in the transport of cholesterol from the lysosome to the plasma membrane via a lysosome-peroxisome membrane contact site.
Medical subject headings
- Cholesterol
- Lysosomes
- Peroxisomes
- RNA, Small Interfering