Hold the salt: vasopressor role for BDNF.
editorial · Level V
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- Record sourced from PubMed, PMID 25863241.
- Also identified by DOI 10.1016/j.cmet.2015.03.015 and PMC identifier 5840492.
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Abstract
In a recent publication in Neuron, Choe et al. (2015) demonstrate that brain-derived neurotrophic factor (BDNF) signaling mediates salt-induced blood pressure elevation by increasing the excitability of hypothalamic vasopressin-secreting neurons. These findings suggest complex roles for BDNF in adaptive cardiovascular responses to physiological challenges and in the pathogenesis of hypertension.
Medical subject headings
- Baroreflex
- Blood Pressure
- Brain-Derived Neurotrophic Factor
- Sodium Chloride, Dietary
- Symporters
- Vasopressins