Inflammasome inhibition: putting out the fire.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25863243.
- Also identified by DOI 10.1016/j.cmet.2015.03.012.
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Abstract
NLRP3-inflammasome activates caspase-1 and processes pro-IL-1β and pro-IL-18 into the active cytokines. Two recent studies describe specific inhibitors of NLRP3 inflammasome that inhibit IL-1β release and inflammation. The specificity and potency of these compounds gives hope that a targeted approach to inhibit NLRP3-driven inflammation may be just around the corner.
Medical subject headings
- 3-Hydroxybutyric Acid
- Carrier Proteins
- Caspase 1
- Cryopyrin-Associated Periodic Syndromes
- Encephalomyelitis, Autoimmune, Experimental
- Heterocyclic Compounds, 4 or More Rings
- Inflammasomes
- Interleukin-1beta
- Monocytes
- Multiple Sclerosis
- Sulfones