A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25865668.
- Also identified by DOI 10.1038/ncomms7820 and PMC identifier 4403379.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.
Medical subject headings
- Guanine Nucleotide Exchange Factors
- Long-Term Potentiation
- Nociception
- Pain
- Spinal Cord Dorsal Horn
- Synapses