A resource for cell line authentication, annotation and quality control.
basic_science · Level V
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- Record sourced from PubMed, PMID 25877200.
- Also identified by DOI 10.1038/nature14397.
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Abstract
Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.