Beyond 3D culture models of cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25877888.
- Also identified by DOI 10.1126/scitranslmed.3009367 and PMC identifier 5063633.
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Abstract
The mechanisms underlying the spatiotemporal evolution of tumor ecosystems present a challenge in evaluating drug efficacy. In this Perspective, we address the use of three-dimensional in vitro culture models to delineate the dynamic interplay between the tumor and the host microenvironment in an effort to attain realistic platforms for assessing pharmaceutical efficacy in patients.
Medical subject headings
- Neoplasms
- Tumor Microenvironment