Mimicking membrane-related biological events by DNA origami nanotechnology.

Suzuki, Yuki; Endo, Masayuki; Sugiyama, Hiroshi · ACS Nano · 2015

basic_science · Level V

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Abstract

One of the potential applications of DNA nanotechnology is the construction of two- or three-dimensional nanostructures that mimic the function of existing biological molecules. In this issue of ACS Nano, Kocabey et al. demonstrate that lipid-bilayer-anchored DNA origami structures can be assembled into prescribed superstructures in a programmed manner. The reported DNA-based artificial system can mimic the dynamic assembly of membrane-associated protein clusters that play an essential role in deformation of cellular membranes.

Medical subject headings