Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25881025.
- Also identified by DOI 10.1002/adhm.201500197 and PMC identifier 4529738.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.
Medical subject headings
- Cell Movement
- Collagen
- Fibroblasts
- Models, Biological
- Tissue Scaffolds