Systems biology of diuretic resistance.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25893597.
- Also identified by DOI 10.1172/JCI81505 and PMC identifier 4463215.
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Abstract
Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall process involves interactions among six different cell types in the kidney.
Medical subject headings
- Blood Pressure
- Chlorides
- Gitelman Syndrome
- Natriuresis
- Nephrons
- Renal Reabsorption