CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 25895986.
- Also identified by DOI 10.1093/infdis/jiv233 and PMC identifier 4601918.
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Abstract
Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.
Medical subject headings
- Contraceptives, Oral, Combined
- Levonorgestrel
- Medroxyprogesterone Acetate
- Receptors, CCR5