Examining the utility of patient-derived xenograft mouse models.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25907221.
- Also identified by DOI 10.1038/nrc3944.
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Abstract
Patient-derived xenograft (PDX) models are now being widely used in cancer research and have the potential to greatly inform our understanding of cancer biology. However, many questions remain, especially regarding the ability of PDX models to affect clinical decision making. With these points in mind, we asked three scientists to give their opinions on the generation and uses of PDX models and the future of this field.
Medical subject headings
- Neoplasm Transplantation
- Neoplasms
- Neoplasms, Experimental
- Transplantation, Heterologous