Global spectrum of copy number variations reveals genome organizational plasticity and proposes new migration routes.
Where this comes from
- Record sourced from PubMed, PMID 25909454.
- Also identified by DOI 10.1371/journal.pone.0121846 and PMC identifier 4409114.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones.
Medical subject headings
- DNA Copy Number Variations
- Genetics, Population
- Genome, Human
- Genomics
- Human Migration