Natural evolution of broadly neutralizing antibodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25910199.
- Also identified by DOI 10.1016/j.cell.2015.04.007 and PMC identifier 4426205.
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Abstract
Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.
Medical subject headings
- Antibodies, Neutralizing
- B-Lymphocytes
- Evolution, Molecular
- HIV Infections
- HIV-1