Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25910200.
- Also identified by DOI 10.1016/j.cell.2015.04.006.
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Abstract
The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins. Ticau et al. use single-molecule imaging to reveal how ORC, Cdc6, and Cdt1 cooperate to load MCM2-7 onto DNA, enabling bidirectional replication.
Medical subject headings
- DNA Replication
- Minichromosome Maintenance Proteins
- Origin Recognition Complex
- Saccharomyces cerevisiae