Tramadol in palliative care #290.

Pruskowski, Jennifer; Arnold, Robert M · J Palliat Med · 2015

Level V

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Abstract

Tramadol has an important position as a Step II agent on the WHO pain ladder, where it is effective for a variety of syndromes in patients with mild to moderate pain intensity. Its recommended dosing adjustments, potential ceiling effect, cost, pertinent drug interactions, and risk for significant adverse drug reactions may limit its chronic use in patients with significant pain.

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