Downregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25928067.
- Also identified by DOI 10.1371/journal.pone.0122679 and PMC identifier 4415816.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BRAF activated non-coding RNA (BANCR), a long non-coding RNA (lncRNA), is crucial for cell migration in melanoma cells and non-small cell lung cancer (NSCLC) cells. However, little is known regarding the role of this gene in the proliferation of colorectal cancer. Therefore, we investigated the involvement of BANCR in the proliferation of colorectal cancer cells. In this study, we show that BANCR expression was significantly down-regulated in colorectal cancer tissues compared with normal tissues, and overexpression of BANCR suppressed colorectal cancer cell growth in vitro and in vivo. We also determined that pCDNA-BANCR-mediated colorectal cancer cell proliferation was associated with induction of G0/G1 cell-cycle arrest and apoptosis enhancement through regulation of p21, and its effects were most likely posttranscriptional. Taken together, our findings suggest that down-regulation of BANCR contributes to the proliferation of colorectal cancer cells, at least in part, through the regulation of p21 protein.
Medical subject headings
- Colorectal Neoplasms
- Cyclin-Dependent Kinase Inhibitor p21
- G1 Phase Cell Cycle Checkpoints
- Gene Expression Regulation, Neoplastic
- Neoplasm Proteins
- RNA, Long Noncoding
- RNA, Neoplasm
- Resting Phase, Cell Cycle