Abdominal obesity: a marker of ectopic fat accumulation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25932676.
- Also identified by DOI 10.1172/JCI81507 and PMC identifier 4463217.
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Abstract
In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded that an abdominal distribution of fat for a given BMI is associated with increased insulin resistance and risk of developing type 2 diabetes and cardiovascular disease. The correlation between abdominal fat and metabolic dysfunction has since been validated in many studies, and waist circumference is now a criterion for the diagnosis of metabolic syndrome. Several mechanisms for this relationship have been postulated; however, we now know that visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue cannot accommodate excess fat because of its limited expandability.
Medical subject headings
- Obesity, Abdominal