Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
basic_science · Level V
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- Record sourced from PubMed, PMID 25939062.
- Also identified by DOI 10.1038/nm.3855 and PMC identifier 4862411.
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Abstract
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.
Medical subject headings
- Benzazepines
- Brain Stem Neoplasms
- Glioma
- Hydroxamic Acids
- Indoles
- Pyrimidines