S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25939735.
- Also identified by DOI 10.1002/adhm.201400841 and PMC identifier 4640194.
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Abstract
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor.
Medical subject headings
- Nanoparticles
- Polypropylenes
- Sulfhydryl Compounds