Emergence of Multidrug-Resistant Influenza A(H1N1)pdm09 Virus Variants in an Immunocompromised Child Treated With Oseltamivir and Zanamivir.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 25943200.
- Also identified by DOI 10.1093/infdis/jiv245.
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Abstract
Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase (NA). When phenotypically evaluated by NA inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by 4 NA inhibitors: oseltamivir, zanamivir, peramivir, and laninamivir.
Medical subject headings
- Antiviral Agents
- Drug Resistance, Viral
- Enzyme Inhibitors
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Neuraminidase