DhITACT: DNA Hydrogel Formation by Isothermal Amplification of Complementary Target in Fluidic Channels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25946166.
- Also identified by DOI 10.1002/adma.201500414.
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Abstract
DNA hydrogel formation by isothermal amplification of complementary targets in microfluidic channels (DhITACT) is a new platform for rapid and accurate detection of infectious pathogens. DNA hydrogel is formed in situ within microfluidic channels by the isothermal rolling circle amplification process upon the selective binding of target strands from the biological fluid. Once the volume of DNA hydrogel sufficiently enlarges, it can selectively block the matching channels with target pathogens.
Medical subject headings
- DNA
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Lab-On-A-Chip Devices
- Nucleic Acid Amplification Techniques
- Temperature