Adult stem-like cells exclude "older" mitochondria.
Where this comes from
- Record sourced from PubMed, PMID 25955200.
- Also identified by DOI 10.1016/j.cmet.2015.04.023 and PMC identifier 4428616.
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Abstract
Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.
Medical subject headings
- Cell Division
- Cellular Senescence
- Mitochondria
- Stem Cells