Modeling the aging heart: from local respiratory defects to global rhythm disturbances.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25955202.
- Also identified by DOI 10.1016/j.cmet.2015.04.024 and PMC identifier 4816650.
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Abstract
In this issue, Baris et al. (2015) describe cardiac rhythm abnormalities in a mouse model of mitochondrial dysfunction in widely distributed cells of the aging human heart. How do a few metabolically challenged cells disrupt cardiac rhythm? We suggest that these cells provide "crystallization centers" for latent dysfunctional zones to allow arrhythmia emergence.
Medical subject headings
- Aging
- Arrhythmias, Cardiac
- DNA, Mitochondrial
- Mitochondria
- Mitochondrial Diseases
- Oxygen