Come to Where Insulin Resistance Is, Come to AMPK Country.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25955203.
- Also identified by DOI 10.1016/j.cmet.2015.04.021.
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Abstract
The link between smoking and insulin resistance, despite weight loss, is well established; however, the underlying mechanisms remain elusive. A recent article published in Nature Medicine by Wu et al. (2015) reports that nicotine, the main bioactive component of tobacco smoke, activates AMPKα2 in adipocytes, leading to impaired insulin sensitivity.
Medical subject headings
- AMP-Activated Protein Kinases
- Adipocytes
- Dual Specificity Phosphatase 1
- Insulin Receptor Substrate Proteins
- Insulin Resistance
- Nicotine