SnapShot: Insulin/IGF1 Signaling.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25957692.
- Also identified by DOI 10.1016/j.cell.2015.04.041.
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Abstract
The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.
Medical subject headings
- Insulin
- Insulin-Like Growth Factor I
- Signal Transduction